New Drugs from Rett Syndrome Research

Rett syndrome is a genetic disorder that may result in both intellectual disability and seizures. Using an animal model of Rett syndrome, Dr. James Eubanks at the Krembil Research Institute has found that "Rett-like" mice have an overly active protein called histone deacetylase 6 (HDAC6). When the over-activity of HDAC6 is stopped in the "Rett-like" mice, their seizures are greatly reduced. Dr. Eubanks and his collaborators Drs. Liang Zhang, Miguel Cortez and Carter Snead are trying to see if compounds that stop HDAC6 activity will stop seizures in other animal epilepsy models. If so, Dr. Eubanks will begin work with EpLink's industrial partners to develop an entirely new type of anti-seizure medication.

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