Understanding the Brain Changes that Arise with Cortical Dysplasia

Image Citation Source by Jacopo Werther used under CC by 2.0
Cortical dysplasia is when brain cells in the cortex (the outer layer of the brain) do not undergo adequate development. People with cortical dysplasia are more likely to develop drug-resistant epilepsy during their lifetime, and often have differences in the way their cells are organized within the brain. Depending on the individual and their development, this may mean that identifying critical brain regions before seizure surgery – such as those responsible for movements and sensations – may be difficult, varying from person to person.

Dr. Jorge Burneo and his colleagues at Western University are using functional magnetic resonance imaging (fMRI) to visualize the activity of specific brain regions in people with cortical dysplasia. Results from Dr. Burneo’s recent publication show that people with cortical dysplasia have differences in the brain areas that are activated during movements and sensations - which need to be identified before surgery.

With this project still ongoing and participants being recruited, Dr. Burneo and his colleagues hope to show the importance of performing fMRI before surgery to identify which brain areas to remove and which to preserve.

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Status: Recruiting

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