Creating a Brain Atlas for Image-Guided Seizure Surgery

Image Citation Source by Aaron G. Filler, MD, PhD used under CC by-sa 3.0
Seizure surgery is a potential treatment option for people that have focal seizures – seizures that are localized to one area of the brain. One of the goals of seizure surgery is to remove the injured or overactive area of the brain, which can help to manage or even cure epilepsy.

Researchers are constantly looking for better ways to find and image the brain injury, and then accurately remove it during surgery without affecting nearby brain regions. For instance, tractography – a specialized magnetic resonance imaging (MRI) technique – can be used to construct 3D models of neuron pathways (known as tracts) in the brain. Tractography can be helpful in accurately identifying which brain regions need to be removed, reducing losses in brain function after surgery.

Drs. Ali Khan and Terry Peters in London, Ontario are also investigating new MRI techniques to measure abnormal structure in the brain, and using brain tissue recovered from surgery and machine learning approaches to help fine-tune detection of brain areas that may be the source of seizures.

Overall, their research aims to improve the efficacy of neuroimaging in the treatment of epilepsy, which they hope will translate into more effective surgery to reduce/treat seizures, less invasive surgeries to reduce neurological deficits that affect quality of life, and earlier or more accurate diagnoses that can improve access to surgery.

Researcher(s): ,
Status: Recruiting

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