Creating a Brain Atlas for Image-Guided Seizure Surgery

Image Citation Source by Aaron G. Filler, MD, PhD used under CC by-sa 3.0
Seizure surgery is a potential treatment option for people that have focal seizures – seizures that are localized to one area of the brain. One of the goals of seizure surgery is to remove the injured or overactive area of the brain, which can help to manage or even cure epilepsy.

Researchers are constantly looking for better ways to find and image the brain injury, and then accurately remove it during surgery without affecting nearby brain regions. For instance, tractography – a specialized magnetic resonance imaging (MRI) technique – can be used to construct 3D models of neuron pathways (known as tracts) in the brain. Tractography can be helpful in accurately identifying which brain regions need to be removed, reducing losses in brain function after surgery.

Drs. Ali Khan and Terry Peters in London, Ontario plan to conduct a clinical trial - in collaboration with Synaptive Medical - using tractography. Their trial will specifically look at targeted removal of the anterior temporal lobe (located at the side of the brain), while avoiding neuron pathways related to vision. With improvements in imaging, the hope is that fewer patients will have vision problems, which can help patients regain their driver’s license after seizure surgery.

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Status: Recruiting

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